Genes in Alcoholic Liver Disease: A Complex Interplay

Alcohol-related liver disease is a major public health problem, with varying clinical course and often devastating consequences. Its spectrum can vary from alcohol-related fatty liver, alcoholic hepatitis, cirrhosis, hepatocellular carcinoma. Multiple environmental, genetic, socio-economic epigenetic factors are intrinsically involved, affecting behavior progression. Recent advances in genome-wide association studies have identified multiple genetic polymorphisms that may affect the pathophysiological process, turn, Although present understanding of this complex process remains nascent at best, there an ardent need to incorporate available markers into diagnostic prognostic algorithms. This pave way for future research targeted therapies.